Research Interests
The endoplasmic reticulum (ER) is the first compartment of the secretor pathway. Plasma membrane receptors, ion channels, hormones and secreted enzymes are few examples of proteins which are being processed and sorted for vesicular transport in the ER. Mistakes in sorting lead to the development of variety of diseases, ranging from hemochromatosis, cystic fibrosis or hereditary emphysema to Pelizaeus-Merzbacher or Alzheimer's neurodegeneration. Viruses such as the cytomegalovirus, HIV-1 Epstein-Barr and many others manipulate ER sorting to evade immune surveillance, a specialized function of the compartment. Dr. Aridor is utilizing a variety of molecular biochemical and cellular techniques to unravel the molecular basis of ER sorting.
Representative Publications
- p125A (Sec23ip) couples COPII coat assembly with donor-acceptor membrane organization to facilitate tunnel-based traffic Long KR, Singh G, Villemeur M, Brouwers N, Malhotra V, Raote I, Aridor M. bioRxiv 2025.05.07.652703; doi: https://doi.org/10.1101/2025.05.07.652703
- Endoplasmic reticulum exit sites are segregated for secretion based on cargo size.
Saxena S, Foresti O, Liu A, Androulaki S, Pena Rodriguez M, Raote I, Aridor M, Cui B, Malhotra V. Dev Cell. 2024 Oct 7;59(19):2593-2608.e6. doi: 10.1016/j.devcel.2024.06.009. Epub 2024 Jul 10.PMID: 38991587 link - A tango for coats and membranes: New insights into ER-to-Golgi traffic. Aridor M. Cell Rep. 2022 Jan 18;38(3):110258. doi: 10.1016/j.celrep.2021.110258. link